pentobarbital will decrease the extent or effect of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will reduce the extent or result of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration. Strong or average CYP3A inducers